PUBLICATIONS
2026
70. Zhai, Haiwei, Xiaowei Jin, Amir Ostadi Moghaddam, Matthew F. Spieker, Kristina Seiffert-Sinha, Animesh A. Sinha, Ruiguo Yang, and Fanben Meng. “3D organotypic skin models recapitulate autoantibody-driven pemphigus pathomechanisms and targeted therapeutic response.” Science Advances 12, no. 2 (2026): eadz5003.
69. Mottini, Vittorio, Liuxi Xing, Yulu Cai, Charlie Meilinger, Soham Inamdar, Xiang Calvin Chen, Bahareh Tajvidi Safa et al. “Age-adaptive polymeric skin electronics enhance neural data and machine learning accuracy” Device (2026), 4(1).
2025
68. Minnick, Grayson, Timothy Goldsmith, Bahareh Tajvidi Safa, Amir Ostadi Moghaddam, Jordan Rosenbohm, Nickolay V. Lavrik, Wei Gao, and Ruiguo Yang. Toward Standardized Microscale Tensile Testing for Two‐Photon Polymerization‐Fabricated Materials in Liquid. Small Science (2025): 2500228.
67. Moghaddam, Amir Ostadi, Xiaowei Jin, Haiwei Zhai, Bahareh Tajvidi Safa, Kristina Seiffert-Sinha, Merced Leiker, Jordan Rosenbohm, Fanben Meng, Animesh A. Sinha, and Ruiguo Yang, Data-Driven Image Analysis to Determine Antibody-Induced Dissociation of Cell-Cell Adhesion and Antibody Pathogenicity in Pemphigus Vulgaris, PNAS Nexus (2025) 4, 8.
66. Xiaowei Jin, Jordan Rosenbohm, Eunju Kim, Bahareh Tajvidi Safa, Amir Ostadi Moghaddam, Kristina Seiffert-Sinha, Merced Leiker, Eljiah Jones, Haiwei Zhai, Sindora R Baddam, Grayson Minnick, Yucheng Huo, James K Wahl III, Fanben Meng, Changjin Huang, Jung Yul Lim, Daniel E Conway, Animesh A Sinha, Ruiguo Yang, Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions, iScience, (2025) 28, 8, 113081.
65. Bahareh Tajvidi Safa, Jordan Rosenbohm, Amir Monemian Esfahani, Grayson Minnick, Amir Ostadi Moghaddam, Nickolay V. Lavrik, Changjin Huang, Guillaume Charras, Alexandre Kabla, Ruiguo Yang, Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells, Communications Biology, (2025) 8, 843.
2024
64. Lorenzen, Sawyer R., Justin R. Brooks, Tyler C. Heiman, and Ruiguo Yang, Porous Substrate-Based Electroporation with Transepithelial Electrical Impedance Monitoring, Journal of Visualized Experiments (JoVE) 211 (2024): e66971.
63. Qin, Xianming, Xianglian Liu, Shuo Liu, Chuanyu Zhang, Ningning Bai, Xue Li, Weidong Wang, Ruiguo Yang et al., Movable surface acoustic wave tweezers: a versatile toolbox for micromanipulation, Microsystems & Nanoengineering 10, no. 1 (2024): 155.
62. Bouzid, Tasneem, Eunju Kim, Brandon D. Riehl, Ruiguo Yang, Viswanathan Saraswathi, Jason K. Kim, and Jung Yul Lim, Mechanical Stretch Control of Adipocyte AKT Signaling and the Role of FAK and ROCK Mechanosensors, Bioengineering 11, no. 12 (2024): 1279.
61. Bahareh Tajvidi Safa, Changjin Huang, Alexandre Kabla, Ruiguo Yang, Active Viscoelastic Models for Cell and Tissue Mechanics, Royal Society Open Science, 11 (4), 231074, 2024.
60. Justin R. Brooks, Tyler C. Heiman, Sawyer R. Lorenzen, Ikhlaas Mungloo, Siamak Mirfendereski, Jae Sung Park, and Ruiguo Yang. Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label‐Free Delivery. Small (2024): 2310221.
59. Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, and Jung Yul Lim. YAP mechanotransduction under cyclic mechanical stretch loading for mesenchymal stem cell osteogenesis is regulated by ROCK. Frontiers in Bioengineering and Biotechnology 11 (2024).
2023
58. Justin R Brooks, Tyler C Heiman, Sawyer R Lorenzen, Ikhlaas Mungloo, Siamak Mirfendereski, Jae Sung Park, Ruiguo Yang, Transepithelial electrical impedance increase following porous substrate electroporation enables label-free delivery, bioRxiv, 2023.10.17.562630.
57. John M Kapitan, Grayson Minnick, Brennan P Watts, Nengjian Huang, Mark A Rose, Ruiguo Yang, Stephen A Morin, Photografting of Surface‐Assembled Hydrogel Prepolymers to Elastomeric Substrates for Production of Stimuli‐Responsive Microlens Arrays, Advanced Functional Materials. (2023), 2305711.
56. Jaideep Sahni, Mehwish Arshad, Morgan A. Schake, Justin R. Brooks, Ruiguo Yang, Peter D. Weinberg, Ryan M. Pedrigi, Characterizing eNOS Expression and Nuclear Morphology in Vascular Endothelial Cells Subjected to a Continuous Range of Wall Shear Stress Magnitudes and Directionality, Journal of The Mechanical Behavior of Biomedical Materials. (2023), 137:105545.
2022
55. Jordan Rosenbohm, Grayson Minnick, Bahareh Tajvidi Safa, Amir M. Esfahani, Xiaowei Jin, Haiwei Zhai, Nickolay V. Lavrik, Ruiguo Yang. A Multi-Material Platform for Imaging of Single Cell-Cell Junctions under Tensile Load Fabricated with Two-Photon Polymerization, Biomedical Microdevices (2022), 24(4):33.
54. Grayson Minnick, Bahareh Tajvidi Safa, Jordan Rosenbohm, Nickolay V. Lavrik, Justin Brooks, Amir M. Esfahani, Fanben Meng, Benjamin Richter, Wei Gao, Ruiguo Yang, Two-Photon Polymerized Shape Memory Microfibers: A New Mechanical Characterization Method in Liquid, Advanced Functional Materials (2022), 10.1002/adfm.202206739.
53. Haiwei Zhai, Xiaowei Jin, Grayson Minnick, Jordan Rosenbohm, Ruiguo Yang, Fanben Meng. Spatially Guided Construction of Multilayered Epidermal Models Recapturing Structural Hierarchy and Cell-Cell Junctions, Small Science (2022), 10.1002 /smsc.202200051.
52. Bouzid, Tasneem, Amir Monemian Esfahani, Bahareh Tajvidi Safa, Eunju Kim, Viswanathan Saraswathi, Jason K. Kim, Ruiguo Yang, and Jung Yul Lim. Rho/ROCK mechanosensor in adipocyte stiffness and traction force generation. Biochemical and Biophysical Research Comm. (2022). PMID: 35339750.
51. Justin Brooks, Iklaas Mungloo, Siamek Mirfendereski, Jacob Quint, Dominic Paul, Arian Jaberi, Jae Sung Park, Ruiguo Yang, An Equivalent Circuit Model for Localized Electroporation on Porous Substrates. Biosensors and Bioelectronics (2022). PMCID: PMC8741749.
50. Hang X., He S., Dong Z., Li Y., Huang Z., Zhang Y., Sun H., Lin L., Li H., Wang Y., Liu B., Wu N., Ren T., Fan Y., Lou J., Yang, R., Jiang L., Chang L. (2022), High-Throughput DNA Tensioner Platform for Interrogating Mechanical Heterogeneity of Single Living Cell, Small, 10.1002/smll.202106196.
49. Esfahani, A.M., Minnick, G., Rosenbohm, J., Zhai, H., Jin, X., Tajvidi Safa, B., Brooks, J., and Yang, R. Microfabricated platforms to investigate cell mechanical properties. Medicine in Novel Technology and Devices (2022) 13:100107.
48. Brooks, J.R., Mungloo, I., Mirfendereski, S., Quint, J.P., Paul, D., Jaberi, A., Park, J.S., and Yang, R. An equivalent circuit model for localized electroporation on porous substrates. Biosensors and Bioelectronics (2022) 199:113862.
2021
47. Hang, Xinxin, Shiqi He, Zaizai Dong, Grayson Minnick, Jordan Rosenbohm, Zhou Chen, Ruiguo Yang, and Lingqian Chang. Nanosensors for Single Cell Mechanical Interrogation. Biosensors and Bioelectronics (2021): 113086.
46. Esfahani, Amir Monemian, Jordan Rosenbohm, Bahareh Tajvidi Safa, Nickolay V. Lavrik, Grayson Minnick, Quan Zhou, Fang Kong, Xiaowei Jin, Eunju Kim, Ying Liu, Yongfeng Lu, Jung Yul Lim, James K Wahl, Ming Dao, Changjin Huang, Ruiguo Yang. Characterization of the strain-rate–dependent mechanical response of single cell–cell junctions. Proceedings of the National Academy of Sciences (PNAS) 118, no. 7 (2021).
45. Jin, X., Rosenbohm, J., Kim, E., Monemian Esfahani, E., Seiffert, K., Wahl, J., Lim, J., Sinha, AA., and Yang, R., 2020. Modulation of Mechanical Stress Mitigates Anti-Dsg3 Antibody-Induced Dissociation of Cell–Cell Adhesion. Advanced Biology, 202000159.
2020
44. Brooks, J., Minnick, G., Mukherjee, P., Jaberi, A., Chang, L., Espinosa, H.D. and Yang, R., 2020. High Throughput and Highly Controllable Methods for In Vitro Intracellular Delivery. Small, p.2004917.
43. Jaberi, A., Monemian Esfahani, A., Aghabaglou, F., Park, J.S., Ndao, S., Tamayol, A. and Yang, R., 2020. Microfluidic Systems with Embedded Cell Culture Chambers for High-Throughput Biological Assays. ACS Applied Bio Materials, 3(10), pp.6661-6671.
42. Perez‐Toralla, K., Olivera‐Torres, A., Rose, M.A., Esfahani, A.M., Reddy, K., Yang, R. and Morin, S.A., 2020. Facile Production of Large‐Area Cell Arrays Using Surface‐Assembled Microdroplets. Advanced Science, 7(15), p.2000769.
41. Derakhshandeh, H., Aghabaglou, F., McCarthy, A., Mostafavi, A., Wiseman, C., Bonick, Z., Rosenbohm, J., Yang, R., Mostafalu, P., Orgill, D, Tamayol, A., (2020). A Wirelessly Controlled Smart Bandage with 3D‐Printed Miniaturized Needle Arrays. Advanced Functional Materials, 1905544.
40. Fang, Y., Gong, H., Yang, R., Lai, K. (2020), An Active Biomechanical Model of Cell Adhesion Actuated by Intracellular Tension, Biophysical Journal, doi.org/10.1016/j.bpj.2020.04.016
39. Riehl, B. D., Kim, E., Lee, J. S., Duan, B., Yang, R., Donahue, H. J., & Lim, J. Y. (2020). The Role of Fluid Shear and Metastatic Potential in Breast Cancer Cell Migration. Journal of Biomechanical Engineering, 142(10).
2019
38. Bouzid, T., Kim, E., Riehl, B. D., Esfahani, A. M., Rosenbohm, J., Yang, R., … & Lim, J. Y. (2019). The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate. Journal of Biological Engineering 13(1), 1-12.
37. Shradhanjali, A., Riehl, B. D., Duan, B., Yang, R., & Lim, J. Y. (2019). Spatiotemporal characterizations of Spontaneously Beating cardiomyocytes with Adaptive Reference Digital image correlation. Scientific Reports 9(1), 1-10.
36. Sun, Z., Cheng, Y., Xi, N., Yang, R., Yang, Y., Chen, L., & Song, B. (2019). Characterizing AFM tip lateral positioning variability through non-vector space control-based nanometrology. IEEE Trans. on Nannotechnology, 19, 56-60
35. Monemian Esfahani, A., Rosenbohm, J., Reddy, K., Jin, X., Bouzid, T., Riehl, B., … & Yang, R. (2019). Tissue Regeneration from Mechanical Stretching of Cell–Cell Adhesion. Tissue Engineering, Part C, 25(11), 631-640.
34. Chang, Lingqian, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, and Yubo Fan. Wearable Devices for Single-Cell Sensing and Transfection. Trends in Biotechnology (2019).
33. Yang, Y., Zeng, B., Sun, Z., Esfahani, A. M., Hou, J., Jiao, N. D., … & Yang, R. (2019). Optimization of Protein–Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy. IEEE Transactions on Nanotechnology, 18, 509-517.
32. J. Cai, R. Yang, X. Wang, and J. Feng. Effect of Initial Imperfections of Struts on the Mechanical Behavior of Tensegrity Structures. Composite Structures, 2019.
2018
31. W. Bai, T. Kuang, C. Chitrakar, R. Yang, S. Li, D. Zhu, and L. Chang. Patchable Micro/Nanodevices Interacting with Skin. Biosensors and Bioelectronics, 2018.
30. A. Monemian Esfahani, W. Zhao, J. Y. Chen, C. Huang, N. Xi, J. Xi, & R. Yang. On the Measurement of Energy Dissipation of Adhered Cells with the Quartz Microbalance with Dissipation Monitoring. Analytical Chemistry, 2018. (Cover Article of Analytical Chemistry)
29. X. Wang, J. Cai, R. Yang, J. Feng, Form-finding of deployable mesh reflectors using dynamic relaxation method. Acta Astronautica. 2018 Jun 15.
28. B. Song, Z. Sun, N. Xi, R. Yang, Y. Cheng, L. Chen, L. Dong, Enhanced Non-Vector Space Approach for Nanoscale Motion Control, IEEE Trans. on Nanotechnology, 2018.
27. Y. Yang, J. Yu, A. Monemian Esfahani, K. Seiffert-Sinha, N. Xi, I. Lee, A.A Sinha, L. Chen, Z. Sun, R. Yang and L. Dong , Single-Cell Membrane Drug Delivery using Porous Pen Nanodeposition, Nanoscale, 2018.
26. R. Yang, J. A. Broussard*, K J. Green, and H D. Espinosa, Techniques to stimulate and interrogate cell-cell adhesion mechanics, Extreme Mechanics Letters, Volume 20, 2018, 125-139. (Cover Article of Extreme Mechanics Letters)
25. R. Yang, V. Lemaitre, C. Huang, A. Haddadi, R. McNaughton and H D. Espinosa, The Monoclonal cell line generation and CRISPR/Cas9 manipulation via single cell electroporation, Small,14, 702495, 2018.
2017
24. J. A. Broussard*, R. Yang*, C. Huang*, S. S. P. Nathamgari, A. M. Beese, L. M. Godsel, S. Lee, F. Zhou, N. J. Sniadecki, K J. Green, and H D. Espinosa, The desmoplakin/intermediate filament linkage regulates cell mechanics, Molecular Biology of the Cell, 10.1091/mbc.E16-07-0520, 2017. (*Equal Contribution)
23. Z. Sun, L. Hao, B. Song, R. Yang, Y. Cheng, N. Xi, Asymmetric Hysteresis Modeling and Compensation Approach for Nanorobotic System Motion Control considering Working-range Effect, IEEE Trans. on Industrial Electronics, 99, Mar. 2017, 10.1109/TIE.2017.2677300.
22. R. Yang*, A. Zaheri*, W. Gao*, C. Hayashi and H D. Espinosa, AFM Identification of Beetle’s Exocuticle – Bouligand Structure and Nanofiber Anisotropic Elastic Properties, Advanced Functional Materials, 10.1002/adfm.201603993, 2017 (*Equal Contribution) (Cover Article of Advanced Function Materials)
Before 2017
21. Z. Sun, L. Hao, B. Song, R. Yang and Y. Cheng, Periodic reference tracking control approach for smart material actuators with complex hysteretic characteristics, Smart Materials and Structures, 10(25), 105029:1-16, 2016.
20. R. Yang, B. Song, K. Lai, C. Fung, K. Patterson, C. Qu, H. Chen, K. Seiffert-Sinha, A. A. Sinha and N. Xi, Cellular level robotic surgery: nanodissection of intermediate filaments in live keratinocytes, Nanomedicine: Nanotechnology, Biology, and Medicine, 11(1):137-45, 2015.
19. K. Seiffert-Sinha*, R. Yang*, C. Fung, K. Lai, K. Patterson, A. S. Payne, A. A. Sinha and N. Xi, Nanorobotic investigation identifies novel visual, structural and functional correlates of autoimmune pathology in a blistering skin disease model, PLOS One, 9(9): e106895, 2014. (*Equal Contribution)
18. B. Song, J. Zhao, N. Xi, H. Chen, K. Lai, R. Yang, and L. Chen, Compressive feedback based motion control for nanomanipulation-theory and application, IEEE Trans. on Robotics, 30(1): 103-114, 2014.
17. R. Yang, N. Xi, K. Lai, K. Patterson, C. Qu, B. Zhong and D. H. Wang, Cellular biophysical dynamics and ion channel activities detected by AFM-based nanorobotic manipulator in insulinoma beta-cells, Nanomedicine: Nanotechnology, Biology, and Medicine, 9(5):636-645, 2013.
16. K. Patterson*, R. Yang*, B. Zeng, S. Wang, N. Xi and M. D. Basson, Measurement of cationic and intracellular modulation of integrin binding affinity by AFM-based nanorobot, Biophysical Journal, 105:1-8, 2013. (*Equal Contribution)
15. N. Xi, R. Yang, C. Fung, K. Lai, B. Song, K. Seiffert-Sinha and A. A. Sinha, Modeling and experimental verifications of cell tensegrity, Modeling and Simulation of Micro/Nano Devices and Systems, N. Xi; M. Zhang; G. Li (Eds.), Taylor and Francis, 87-102, 2013. (Book Chapter)
14. N. Xi, R. Yang, B. Song, K. Lai, H. Chen, J. Y. Chen, L. Penn and J. Xi, Developing dynamics model for epidermal growth factor (EGF) induced cellular signaling events, Modeling and Simulation of Micro/Nano Devices and Systems, N. Xi; M. Zhang; G. Li (Eds.), Taylor and Francis, 69-85, 2013. (Book Chapter)
13. N. Xi, B. Song, R. Yang, K. Lai, H. Chen, C. Qu, and L. Chen, Video rate atomic force microscopy, IEEE Nanotechnology Magazine, 7(1):4-8, 2012.
12. Song, R. Yang, N. Xi, K. Patterson, C. Qu and K. Lai, Cellular-Level surgery using nanorobots, J. Laboratory Automation, 17(6):425-434, 2012.
11. R. Yang, J. Y. Chen, N. Xi, K. Lai, C. Qu, C. Fung, L. S. Penn and J. Xi, Characterization of mechanical behavior of an epithelial monolayer in response to epidermal growth factor stimulation, Exp. Cell Research, 318: 521-526, 2012.
10. B. Gao, J. Xu, J. Zhao, N. Xi, Y. Shen and R. Yang, A humanoid neck system featuring low motion-noise, J. of Intelligent and Robotic Systems, 67(2):101-116, 2012.
9. J. Xi, L. S. Penn, N. Xi, J. Y. Chen and R. Yang, Dynamic mechanical response of epithelial cells to epidermal growth factor, Viscoelasticity -from theory to biological applications, Juan de Vicente (Ed.), InTech, 171-186, 2012. (Book Chapter)
8. R. Yang, N. Xi, K. Lai, B. Zhong, C. Fung, C. Qu and D. H. Wang, Nanomechanical analysis of insulinoma cells by atomic force microscopy after glucose and capsaicin stimulation, Acta Pharmacologica Sinica, 32(6):853-860, 2011.
7. M. Tan*, Yun Li*, R. Yang, N. Xi and Y. Sun, Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid, PLOS One, 6(11) e27726:1-9, 2011. (*Equal Contribution)
6. C. Fung, N. Xi, R. Yang, K. Seiffert-Sinha, K. Lai and A. A. Sinha, Quantitative analysis of human keratinocyte cell elasticity using atomic force microscopy, IEEE Trans. on Nanobioscience, 10(1):9-15, 2011.
5. N. Xi, B. Song, R. Yang and K. Lai, Augmented reality for nanomanipulation, Handbook of Augmented Reality Technologies and Applications, Borko Furht (Ed.), Springer, Part 2, 435-447, 2011. (Book Chapter)
4. N. Xi, C. Fung, R. Yang, K. Lai, D. H. Wang, K. Seiffert-Sinha, A. A. Sinha, G. Li and L. Liu, Atomic force microscopy as nanorobot, Atomic Force Microscopy in Biomedical Research Methods and Protocols, 1st Ed., P.C.Braga, D. Ricci Ed., Springer, 736:485-503, 2011. (Book Chapter)
3. N. Xi, R. Yang, K. Lai, B. Song, B. Gao, J. Shi and C. Su, Motion controller for Atomic Force Microscopy base nanobiomanipulation, Control Technologies for Emerging Micro and Nanoscale Systems, 1st Ed., Vol. 413, Eleftheriou, Evangelos; Moheimani, S.O. Reza (Eds.), Zurich: SpringerVerlag, 153-168, 2011. (Book Chapter)
2. N. Xi, C. Fung, R. Yang, K. Seiffert-Sinha, K. Lai and A. A. Sinha, Bionanomanipulation using Atomic Force Microscopy, IEEE Nano Magazine, 4(1):9-12, 2010.
1. C. Fung, K. Seiffert-Sinha, K. Lai, R. Yang, D. Panyard, J. Zhang, N. Xi and A. A. Sinha, Investigation of human keratinocyte cell adhesion using atomic force microscopy, Nanomedicine: Nanotechnology, Biology, and Medicine, 6(1):191-200, 2009.
